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聯系人: 賈經理;胡總

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Chinese Name

中文名


瑞加德松

English Name

英文名


regadenoson

Alias

別名

Lexiscan;1-(6-Amino-9((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide hydrate;2-[(Methylamino)carbony]-1H-pyrazol-1-yl]-adenosine



CAS NO.


313348-27-5;875148-45-1

Formula

分子式


C15H20N806

M.W.

分子量


408.37

Class

分類


原料藥


Regadenoson是一種A2A腺苷受體激動劑是一種冠狀動脈血管擴張劑。
適應證:Lexiscan是一種藥理學應激劑適用于在不能進行適當運動負荷患者中放射性核素心肌灌注顯像(MPI)。
劑量和用法:Lexiscan推薦的劑量是5 mL (0.4 mg regadenoson)通過迅速靜脈注射;隨后立即用鹽水和放射性藥物沖洗。
禁忌證:有二級或三級AV阻滯,或竇房結功能失調患者不能給予Lexiscan除非患者 有功能良好的人工心臟起搏器 
不良反應:對Lexiscan最常見(發生率 ≥ 5%)不良反應是呼吸困難、頭痛、面紅、胸部不適、眩暈、心絞痛、胸痛、和惡心。
藥物相互作用:甲基黃嘌吟類,如,咖啡因和茶堿,可能干擾Lexiscan的活性。 氨茶堿可能用于減輕嚴重和/或對Lexiscan的持久不良反應。



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[9]GAEMPERLI O,SCHEPIS T,KOEPFLI P,et al.Interaction ofcaffeine with regadenoson-induced hyperemic myocardial bloodflow as measured by positron emission tomography:arandomized,double-blind,placebo-controlled crossover trial[J].JAm Coll Cardiol,2008,51(3):328-329.
[10]ZHAO G,MESSINA E,XU X,et al.Caffeine attenuates theduration of coronary vasodilation and changes in hemodynamicsinduced by regadenoson(CVT-3146),a novel adenosine A2Areceptor agonist[J].J Cardiovasc Pharmacol,2007,49(6):369-375.
[11]LIEU HD,SHRYOCK JC,von MERING GO,et al.Regadenoson,a selective A2A adenosine receptor agonist,causes dose-dependent increases in coronary blood flow velocity in humans[J].J Nucl Cardiol,2007,14(4):514-520.
[12]HENDEL RC,BATEMAN TM,CERQUEIRA MD,et al.Initialclinical experience with regadenoson,a novel selective A2Aagonist for pharmacologic stress single-photon emission computedtomography myocardial perfusion imaging[J].J Am Coll Cardiol,2005,46(11):2069-2075.
[13]CERQUEIRA MD,NGUYEN P,STAEHR P,et al.ADVANCE-MPI Trial Investigators.Effects of age,gender,obesity,anddiabetes on the efficacy and safety of the selective A2A agonistregadenoson versus adenosine in myocardial perfusion imaging:integrated ADVANCE-MPI trial results[J].JACC CardiovascImaging,2008,1(3):307-316.
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[15]LEAKER BR,O’CONNOR B,HANSEL TT,et al.Safety ofregadenoson,an adenosine A2A receptor agonist for myocardialperfusion imaging,in mild asthma and moderate asthmapatients:a randomized,double-blind,placebo-controlled trial[J].J Nucl Cardiol,2008,15(3):329-336.
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地址: 江蘇省蘇州市工業園區仁愛路150號C316室 電話:0517-86993111;0512-62729923

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